Endocrine Abstracts

To test the feasibility of reconstructing ex situ an entire bioartificial thyroid gland suitable for transplantation we have bioengineered a rat thyroid lobe using its decellularized stromal / vascular matrix, eventually 3D recellularized with thyroid stem / precursor cells. Sprague-Dawley male rats (220–240 g) were used as thyroid donors, and lobe matrixes obtained by freezing / detergent / enzyme processing. Test matrixes were made electrondense and analyzed by m...

GH and IGF-I exert an important role in the control of bone formation. Osteopenia and osteoporosis are a frequent recurrence in patients with thalassemia. Due to the high prevalence of GH deficiency (GHD) in adult thalassemic patients (Scacchi et al., Clin Endocrinol 2007), we investigated the possible role of GH - IGF-I abnormalities in the pathogenesis of the osteopenia/osteoporosis of this disease.Study: Sixty-four adult thalassemic pati...